Horionic gonadotropin of man (HCG, HCG common, HCG, Total HCG, Total Beta HCG) hormone produced by the placenta during pregnancy, chorionic gonadotropin is a glycoprotein and consists of two alpha and beta subunits. The alpha subunit is homologous to those in the lethenizing, follicularity and thyrotropic hormones, and beta subunits vary and provide biological and immunological specificity. The beta subunit of the HCH and beta subunit LH several common peptide sequences, however, the structure of the carboxyl end they are individual.
After the fertilized egg is implanted into the wall of the uterus, the placenta trophoblasts begin to synthesize the hCG. The active secretion of hCG supports the yellow body, which remains functionally active during the entire period of pregnancy, and produces large progesterone concentrations, physiologically impossible in a non-embled organism. A week after fertilization, the HCG analysis during pregnancy (normal flow) can show a concentration in the analysis of blood for HCG 50 IU / l. During the first six weeks, if you donate blood on hgch, you can see the dynamics, so. The level doubles every 1.5-3 days and continues to increase to the start of the second trimester, after which the pregnancy during the remaining period is gradually decreasing to lower values. The concentration of HCG after childbirth in the blood test at hCG is 5 me / l.
HCG is an excellent marker that helps urgently determine pregnancy. In healthy non-embled women, the concentration of hormone in the blood test on the HCG is from 5.3 me / l to undefined. In the analysis of hCG during pregnancy, its concentration increases, as described above, and there is a gradual decline after the first trimester. Unusually low or rapidly decreasing concentration when analyzing HCG during pregnancy may indicate such pathological conditions as an ectopic pregnancy or a threat to interrupt pregnancy.
The sensitivity of the method (blood for hCG) allows you to digitate the pregnancy already on the second day after the delay of menstruation, but, due to the individual differences in the speed of its synthesis, it is better to take blood on hgch and accordingly to study no earlier than 3-5-5- Day delay in order to avoid false negative results. In case of dubious results, the blood for the HCG should be passed twice with an interval of 2 to 3 days. When determining the completeness of the removal of ectopic pregnancy or abortion, it should be supplied to the hCG no earlier than 1 to 2 days after the operation.
According to the order of the Ministry of Health of the Russian Federation of August 30, 2012 No. 107n when transferring the embryo to the diagnosis of pregnancy by studying the level of chorionic gonadotropin in the blood or in the urine is carried out after 12-14 days from the moment of embryos. Ultrasonic diagnosis of pregnancy is carried out from 21 days after transfer.
Human chorionic gonadotropin refers to biologically active substances. The appearance of this protein in large quantities is a sign of coming pregnancy, it is actively synthesized since the formation of the embryo and to the birth. The hormone ensures the safety and growth of the fetus, stimulates the synthesis of estrogen and progesterone, and at the same time slows down the work of mechanisms responsible for the occurrence of menstruation.
The main task of the chorionic gonadotropin is to maintain the pregnancy itself, the exclusion of the risk of rejection of the fetus. Under the control of hCG, important hormones are developed - progesterone, estrogen. The trimester has not yet been formed fully formed a placenta (approximately 16 weeks), HCG supports the stimulation of a yellow body by developing progesterone.
The patient's blood takes strictly in the morning clock on an empty stomach (8-14 hours of fasting). You can drink only clean water. In the daytime, the analysis can be taken 4 hours after easy snack.
It makes sense to discuss with the attending specialist the feasibility of the study against the background of the reception of certain drugs or after the short period after their cancellation.
This glycoprotein is one of the most important indicators of pregnancy and its prosperous development. HCG consists of two subunits - Alpha and Beta. Alfa-subunit is identical to alpha subunits of pituitary hormones (TSH, FSH and LH). Beta subunit (beta-hCG) hormone is unique.
HCG begins to produce chorion cloth after implantation of the embryo. Beta-hCG level is already 6-8 days after fertilization of the egg makeup allows you to diagnose pregnancy. In the first trimester of pregnancy, HCG supports the yellow body and stimulates the production of progesterone hormones and estrogen necessary to maintain pregnancy. This happens until the fruit fetter system starts to form the necessary hormonal background independently.
In the first weeks of pregnancy, the level of hCG should roughly double every 2 days. The concentration of hCG reaches a maximum of 10-11 weeks of pregnancy, then the HCG level begins to slowly decline.
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