Methipred - a review from the drug.

Nobody will advise to start receiving this poison! A nightmare! From one word "methipred" throws into a tremor. So many sides that you kind of and treat, but much more seriously suffers from the whole organism as a whole. This is a huge pressure, and constant headache, and face, friends do not recognize, still hair on the face and all over the body. Only external eases of the sea, and what inside? In general, I do not advise anyone this poison. In addition to everything from it it is very difficult to peer. Be healthy! I hope you take place without hormones ????

for intake, in / in administration (forms of the usual duration of action) and in / m administration (depot-shapes): primary or secondary insufficiency of adrenal function, congenital hyperplasia of adrenal glands, non-resident thyroiditis, hypercalcemia due to tumor disease , rheumatic diseases, collagen diseases, bubble, bullous herpes dermatitis, heavy multiform erythema, exfoliative dermatitis, severe psoriasis, severe seborrheal dermatitis, heavy allergic diseases, severe acute and chronic allergic and inflammatory processes with eye damage, symptomatic sarcoidosis, Lefeler syndrome (not Berillion, focal or disseminated pulmonary tuberculosis (simultaneously with appropriate anti-tuberculosis chemotherapy), idiopathic thrombocytopenic purple in adults, secondary thrombocytopenia in adults acquired (autoimmune) hemolytic anemia, erythroblasting (red blood cells I), congenital (erythroid) hypoplastic anemia, sharp leukemia in children, palliative therapy for malignant tumors; To achieve remission in nephrotic syndrome, in a critical period with ulcerative colitis and regional enterite, sclerosis in the exacerbation phase; Brain swelling due to a tumor or related to surgical intervention, radiation therapy, cranial trauma; shock due to lack of adrenal cortex or resistant to standard therapy, tuberculous meningitis with a subarachnoid unit or with its threat (together with anti-tuberculosis chemotherapy), trichinosis with damage to the nervous system or myocardium, organ transplantation; Short-term therapy for diseases of the musculoskeletal system of rheumatic and nonspecific genesis.

La introduction to synovial liquid or soft fabrics (depot-shape): auxiliary therapy in the acute period of synovite, rheumatoid arthritis, gout arthritis, epicondylitis, non-specific tendosinovitis, post-traumatic osteoarthrosis.

Based on the official instruction on the use of the drug, approved by the manufacturement company prepared for the electronic publication of the Cellity of Vallel 2016, the update date: 2021. 2. 8

There was a backlog on the ultrasound, then the children himself caught up with everything, only prosecutoron I accept the testimony

with progesterone were wrong, took weeks from 8 to 11 to the floor of the tablet for the night .... From the day another week or two (I do not remember exactly) on the quarter for the night, then canceled. I would not advise you to independently begin to cancel it, the drug is serious, you just decide what doctor to trust and follow his instructions

I drink it from 18 weeks and before the birth will drink, but I have problems with hormones.

The fact is that this drug must prescribe and control the dose of endocrinologist analyzes blood (TSH or 17-way) these drugs are not exactly a gynecologist. I am now I drink Metipred myself. I rent a blood 1 time in a month. For 3 months, only an endocrinologist change the dose (as I was told during pregnancy. Gynecologist and endocrinologist Main doctors)

It is prescribed with elevated men's hormones! I drink 1 tablet, drinking methipred is better in the morning, I will drink until the end of pregnancy, I took it before. That would be appointed due to the lag in the development of the fetus never heard. canceled it in one fell, the less dose like you - it is impossible!

I would at your place listened to the doctor from the LCD and gradually canceled it, since. Methipred for "feeding" sounds like nonsense. I now accept it myself, but I have problems with male harmonies, and I accept through "I don't want" t. The reception of methipred during pregnancy is shown only in exceptional cases and after multiple studies, and our doctors prescribe to everyone. And I did not conduct such "multiple research", but the need for reception confirmed 2 physicians, and I do not want to risk.

I had two frozen pregnancies, dying hormones (while they tried to save), it did not work out, then another doctor turned out that I couldn't have to carry out the therapy that I was prescribed on conservation. After discharge, after the second cleansing of the month, three, as in the trance, the pressure was very felling, the heartbeat was rapidly.

Common to our doctors, it is treated, one is treated, another cripples. Ot, with her husband, two planning clinics were visited - in one appointed everyone "Favorite" methipred, I refused to drink it, t. . Ama-Medic, told me what it was and what happens from him. A completely different treatment was offered about the second clinic, without a methipred, and others. Renate, of course, we will be.

In general, read the article of the girls. It or not drink is a matter of person personally, but let everyone be up to date. "In me, she called a bunch of feelings. Maybe someone knows how reason it is, on their own feelings from drugs, especially the opinions of those who have already born. Well, or Those who do not live in Russia. Link goes to a dear Ciroline.

U - Center of Immunology "Caution, glucocorticoids! Glucocorticoids (HS) (synonym: glucocorticosteroids, GKS) is a group of adrenal cortex hormones. The main representatives of the GCS in the human body are cortisol and cortisone. Under the GCS are often understood not only by the natural hormones of adrenal cortex, but also drugs that are analogues of these hormones.

These drugs include prednisone, dexamethasone and methipred. These drugs are used to treat many diseases as independent or additional therapy. However, only in the countries of the former Soviet Union and Bulgaria use GCS for the treatment of such a state, like non-pending pregnancy.

At the present moment in Russia, and in particular in Moscow, the use of GCS during pregnancy has become so routine procedure that one of the endocrinological laboratories announced a sad competition on the Internet.

The laboratory staff promise to give a bottle of champagne to any pregnant Muscovite over 30 years old, observed in the district w / c, which for the entire period of pregnancy never heard of these drugs. Unfortunately, the bottle still remained unclaimed. Such a large-scale use of potent hormonal means should be based on serious evidence of the safety of such therapy.

However, this cannot be said about the use of glucocorticoids.

Moreover, each pregnant woman should know that the use of GCS during pregnancy inevitably entails serious consequences! Over the years, studies conducted by both animals and man revealed the dependence of the behavior of the offspring on the degree of stressful state of the mother and on the effects of glucocorticoids on the fetus during the period of intrauterine development.

In particular, it was shown that for the human embryo, the impact of stress in the period up to 8 weeks of pregnancy leads to his death, for example, the appointment of dexamethasone for pregnant sheeps during just two days at the end of the first month of pregnancy (which lasts 5 months) led to an increase in blood pressure Yagnyat has already since 3 months of age.

However, the side effect of glucocorticoids was not limited to this. In the conducted studies, a large number of evidence was obtained that the maternal stress during pregnancy or the effect of excess glucocorticoids leads to changes in the structures of the brain of the fetus.

For example, in the offspring of rats underwent decxamethasone in terms of 17-19 days of pregnancy, significant violations of the hormonal exchange occurred between different brain departments were found. Such violations were also expressed in changing behavior (increased excitability), which were caused by a higher level of corticosterone plasma when entering an unfamiliar environment.

Green Martyshki, who received one-time dexamethasone in the second half of pregnancy, made a heaven, which, after any stress, the cortisol was always produced more than in the control group. In addition, they had a decrease of 20-30% of the scope of such a brain structure, as a hippocampus, which is responsible for the memory processes . .

Thus, it was shown that a fine tuning of the hippocamp-hypothalamic-pituitary and adrenal system can be broken as a result of the action Mechanism "Programming". In the future, this leads to a higher than normal, glucocorticoid secretion in adulthood.

The long-term effects of the increased level of glucocorticoid contributes to the development of arterial hypertension and increases the risk of the development of type 2 diabetes. That is why the domestic diagram of the treatment of non-peculiarization of pregnancy by applying GCS is never considered in foreign studies even as possible.

Once there is at least the slightest risk to harm a healthy fruit, such treatment is recognized as inexpedient and even destructive. In the late 1960s, Soviet doctors engaged in the study of endocrine causes of non-leaving pregnancy. Especially interesting in this respect appeared hyperandogenic states, that is, the states in which the woman's developing male genital hormones increases - androgen.

At this time, in large cities, it was possible to diagnose hyperaldogenic states using urine analysis to 17-CC (products of conversion of glucocorticoid and androgens entering the urine). The analysis was carried out in a chemical method and did not require expensive equipment and reagents.

It turned out that the purpose of glucocorticoid preparations (prednisone and dexamethasone) causes a decrease in the stimulation of the adrenal cortex by the pituitary gland, the secretion of 17-ks decreases. The use of GCS in order to treat non-pending pregnancy began in unprecedented holidays in any country scale and began to introduce into everyday obstetric practice.

This was facilitated by several factors. First, the simplicity and external understanding of the action (there is a non-pending pregnancy - see 17-COP, if they are raised - appoint glucocorticoids, prescribed medicine - 17x changed - the result is achieved!). Secondly, imagining the harmlessness of such treatment. And this should be stopped in more detail.

Domestic authors who wrote and continue to write about the harmlessness of GKS during pregnancy, relied on reliable foreign research. However, none of those studies on which they refer do not say about the safety of the therapy they spend! We are talking about completely different therapy.

The appointment of the GKS pregnant woman is once or a short course in the threat of premature labor causes a significant improvement in the ripening of light fetus and dramatically improves perinatal performance.

About the safety of precisely such therapy is argued in the West, and it is such the therapy that was recognized as permissible and relatively safe for the fetus, as compared to the risk to die, and it is used when premature birth is inevitable! At the same time, all researchers note a decrease in mass and disorder of behavior in such kids.