The purpose of the study: Evaluation of the effectiveness and compliance of the use of the drug Polizinaks in the treatment of vulvovaginites caused by aerobic and mixed microflora, in women of reproductive age.
Materials and methods. The study included 36 women reproductive age with the diagnoses of aerobic vulvovaginitis and mixed vulvovaginitis. The study was performed in accordance with international standards and GCP rules. Polizinaks was appointed 1 capsule intravaginally before bedtime for 12 days. The effectiveness of therapy was assessed by clinical data, the results of expanded colposcopy, pH-metry, the state of the microbiocenosis of the vagina by determining the main groups of conditionally pathogenic microorganisms by the method of quantitative polymerase chain reaction in real time.
results. It has been established that the pathogenetically reasonable purpose of the combination of two antibiotics of a wide range of action and the anti-grade made it possible to conduct polyvalent treatment without the negative effects of antibiotics on the normal microflora of the vagina. Based on clinical data, the effectiveness of a 12-day course of treatment as the most optimal elimination of pathogens and reducing the frequency of relapses is proved. Acting selectively on optional-anaerobic microorganisms (Enterobacterium SPP., Streptococcus SPP., Staphylococcus SPP.), Polizinaks does not cause Lactobacillus SPP elimination., Promotes the suppression of the growth of aerobic microflora and creating optimal conditions for the growth of own lactoplora, providing colonization resistance of vaginal biotope and increasing The overall effectiveness of treatment.
Conclusion. Polizinaks is a drug selection for the treatment of vulvovaginites caused by aerobic and mixed microflora, in patients of reproductive age.
Keywords: women of reproductive age, vulvovaginitis, aerobic and mixed microflora, treatment, Polizinaks.
Currently, there is a tendency to an annual increase in the frequency of inflammatory diseases of female genital organs, which often have a long-term recurrent flow with the chroniosis of the inflammatory process . Infections of the lower sections of the genital tract are 57.6% in the structure of all infectious inflammatory diseases .
According to modern researchers, more than 60 phenotypes of microorganisms may be present as part of the vaginal microbiocenosis, but their set is relatively constant if the woman remains healthy for a considerable period of time. Scientists have repeatedly tried to prove the independent etiological role of various conditionally pathogenic microorganisms in the development of vulvovaginites.
However, attempts to search for monofroductors of the inflammatory processes of the urinary tract caused by conditionally pathogenic microorganisms were further disproved by researchers, who have discovered the same microorganisms in almost healthy women.
Thus, a large amount of data on the polyimitic nature of infectious-inflammatory diseases of the urogenital tract has accumulated in the literature. . There are disputes regarding the classification of bacterial vaginites. Some authors tend to interpret bacterial vaginosis as a non-specific inflammatory process, setting the equality between this disease and nonspecific vaginite.
Other researchers consider bacterial vaginity with vaginal dysbacteriosis - self-nosological form. Regarding the etiology of this disease among specialists there is also no uniform opinion . However, today, most researchers consider non-specific bacterial vaginitis as an inflammatory disease, in which the ratio of strict anaerobes to aerobam changes.
In recent years, there has been convincing evidence that polyimicrobial pathological conditions may be associated not only with pathogenic (Neisseria Gonorrhoeae, Trichomonas Vaginalis, Chlamydia Trachomatis, Mycoplasma Genitalium), but also with conditionally pathogenic (aerobic, Optional and bond-anaerobic) microorganisms.
With diseases such as urethritis, vaginitis and cervicitis, the trend towards an increase in the content of facultative-anaerobic and aerobic microorganisms is clearly trained. In addition, the ratio of strict anaerobes and airbones is changed, which highlights mostly representatives of the Enterobacteriaceae and MicrococcaEaE families.
Therapeutic agent Polizinaks is produced in the form of vaginal capsules (candles), 6 or 12 pieces in a blister placed in a cardboard pack.
Polizinaks is a local combined healing agent with antifungal and antibacterial efficacy and used in gynecology. The drug capsules are characterized by bactericidal activity against various microorganisms.
The central effect of the active ingredients of this drug from the group of antibiotics - polymixin B and neomycin is essential to suppressing the activity of many bacterial microorganisms, both gram-positive and gram-negative. Do not show sensitivity to the effects of these drugs anaerobic bacteria and streptococci.
The third antobacterial active ingredient capsules - nastatin - is distinguished by its fungicidal effect in relation to the mushroom strains of the genus Candida, and therefore there is a high efficiency of the drug Polizinaks during thrush. The drug has a beneficial effect on the trophic processes occurring in the mucous membrane, and has a rather extensive spectrum of action, ranging from the thrush and ending with other fungal lesions of the vagina.
When intravaginal use, all three active ingredients capsules are evenly distributed over the entire mucosa of the vagina, where their local fungicidal and bactericidal effects appear. The absorption of the active ingredients of the drug from the vaginal mucosa into systemic bloodstream is almost equal to zero.
As a medical agent for therapy for infectious-inflammatory painful conditions caused by microorganisms sensitive to active ingredients, polyzinaks are prescribed with: nonspecific vaginites, vulvovaginites, fungal vaginites, cervicinites, mixed vaginites.
Polygenx candles are used during pregnancy for disinfection of generic channels before childbirth, as well as in front of surgical operations (they have a contagon effect).
Despite the local impact (the lack of entering the overall blood flow through the mucous membrane), the drug can be applied only by the doctor's prescription. Polizinaks did not pass a sufficient number of research and its full safety for the health of a pregnant woman and the baby is not proven.
Greetings to all those who looked in my review by Polizinaks, this is a drug that prescribes doctors with certain female ailments, bet thrush, inflammation, preparation for interventions. I will talk about my experience in the use of these capsules in different periods of my life. Polizinaks.
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