The lack of lutein phase is one of the frequent causes of infertility in women. In infertility in such cases, as a rule, due to the inability of the fertilized egg to normal nidetization. The lack of lutein phase may have the following varieties:
All this is possible only under the condition of normal regulation of the ripening of the follicle. The framework of this review does not allow detail to dwell on this problem. In a clinical aspect, the following is important:
The population of women with dysfunction of the phase of the yellow body of heterogeneous, and the traditional therapy of exogenous progestins in the second phase of the cycle will be effective only in those patients who do not have a neg-chuck disorder. If the estrogenist stimulation in the first phase of the cycle was much lower than the norm, such treatment will not bring the desired result, since the endometrium will not be able to answer it. The unsuccessful treatment of NLF progestins in the second phase of the cycle is most often due to:
The general conclusion is that the treatment of NLF should begin with the regulation of the follicular phase, and very often it happens (26).
The duration of the lutein phase of the ovulatory menstrual cycle is always the same and amounts to 14 + 1 day.
Thus, the duration of the ovulatory menstrual cycle of a woman is determined by the duration of the proliferative phase, since the duration of the lutein phase is always constant. It also should also be noted that these indicators are applicable only to cycles in which ovulation occurs, that is, ovulatory.
The full-fledged lutein cycle phase is one of the key moments of implantation, since it is known that along with a full-fledged embryo, is a necessary component of the occurrence of pregnancy. Required to form a full-fledged lutein phase change endometrials are the name of secretory transformation.
This process is launched under the influence of progesterone secreted by a yellow body, the function of which in turn regulates the luteinizing hormone (LH).
implantation is possible only in a period of strictly limited period in time, the so-called implantation window, the formation of which is individually in each particular menstrual cycle and is under the influence of hormonal factors, cell adhesion molecules, cell proliferation factors and others. Synchronization between the embryo development stage in which implantation and the availability of the implantation window can lead to the impossibility of the occurrence of pregnancy in this cycle. There are literary data that when applying the stimulation of supervision in the program (ECO), the implantation window shifts in earlier time.
Violations of the formation of a full-fledged lutein phase - its defect (DLF) - can be as an independent cause of implant failures, and to accompany other endometrial infertility factors (polyp endometrial, hyperplastic processes, chronic endometritis and others).
Very important for understanding the factor is that the DLF is a pathological process in endometrial, respectively and to put this diagnosis, only by studying the endometrium into the lutein phase of the cycle. By and large, the DLF is an exceptionally histological diagnosis and unlawful to put a patient with such a diagnosis, focusing, only to the level of progesterone in serum. Although it is definitely that when anneviation or significantly low progesterone, DLF serum in endometrials must be implied and adjustable.
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